Week 1 is always the most difficult to predict NFL games. Week 1 in 2020? Nearly impossible. The pandemic completely altered the offseason and canceled the preseason, meaning there's even more unknown than usual. My best advice is to pick your spots. Find one or two games, and that's it. Let us pick all 16 games.
Underdogs often bark loudest early in the season when point spreads aren't as spot-on, so keep an eye on that. There are a handful of favorable matchups and spreads this week, but it's mostly a lot of stay-away games (Las Vegas at Carolina tops the list). My three most confident picks against the spread are Arizona, Baltimore and Miami.
