Antonio Conte will be hoping his side can take momentum from their 5-0 victory over Everton, on their travels to face Man United on Saturday.
Both sides are still very much battling for a top four spot and although the Red Devils are two places above Tottenham, it is only by two points and the Lilywhites have two games in hand.
Ralf Rangnick's side will be coming into the fixture on the back of a 4-1 defeat to Man City and a couple of extra days' rest on Spurs.