After France's defeat to Ireland on Saturday evening, England will know that wins in their remaining games could well mean the title head to Twickenham with France to play in Paris on the final day, also known as Super Saturday.
Despite defeat to Scotland, England will be confident of doing just that after beating the world champions South Africa in the autumn but they will need a big win against Italy on Sunday afternoon to kick things off.
Eddie Jones has opted for an exciting line-up with Harry Randall being given his first Six Nations start at scrum-half while Jack Nowell is picked on the wing for his first England start since the 2019 World Cup.