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Michael Hornberger, Professor of Applied Dementia Research, University of East Anglia

Is it really possible to have Alzheimer’s yet no symptoms?

Andrey_Popov/Shutterstock

Some people seem to be more resilient to developing Alzheimer’s diseases, despite having the biological hallmarks of the devastating disease. For obvious reasons, scientists are very interested in studying this special group of people.

Alzheimer’s disease, the most common form of dementia, is thought to start because of a build-up of two proteins in the brain: amyloid and tau. Once these proteins accumulate, for yet-to-be-determined reasons, they become toxic to brain cells (neurons) and these cells start dying. As a result, people develop symptoms such as memory loss because the brain can’t function properly with all these dead neurons.

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