Julia Letlow (R) and John Fleming (R) advanced to a June 27 runoff in the Republican primary for U.S. Senate in Louisiana, with 45% and 28% of the vote, respectively. Incumbent Bill Cassidy finished third, with 24% of the vote.
President Donald Trump (R) and Gov. Jeff Landry (R) endorsed Letlow. According to Axios' Alex Isenstadt, heading into the election, "Cassidy — who voted to convict Trump over his role in instigating the Jan. 6 Capitol riot — is the only Republican senator Trump's team is targeting for defeat this primary season." Cassidy said, "I will continue to do a good job when I win re-election. I am a conservative who wakes up every morning thinking about how to make Louisiana and the United States a better place to live."
As of the 2026 election, Letlow represented Louisiana's 5th Congressional District. Letlow earned her bachelor's and master's degrees from the University of Louisiana Monroe and her doctorate from the University of South Florida. She worked as a university professor and administrator before her election to the U.S. House in 2021.