Indian Institute of Science (IISc) researchers have designed a small molecular fluorogenic probe that can sense a specific enzyme linked to the progression of Alzheimer’s disease. Such a probe can easily be fabricated into a strip-based kit that may enable on-site diagnosis.
Alzheimer’s disease, a neurodegenerative disorder, results in memory loss and compromises cognitive abilities in many people beyond the age of 60. Currently used techniques to detect manifestations of the disease (MRI, PET, and CT scans) are complex, expensive, and often produce inconclusive results, according to the researchers.
The molecular fluorogenic probe is designed by Debasis Das, assistant professor in the Department of Inorganic and Physical Chemistry at IISc., and Jagpreet Sidhu, a C.V. Raman postdoctoral fellow in the department.
