Millions of Americans taking GLP-1 drugs like Ozempic, Wegovy, Mounjaro, or Zepbound for diabetes and weight management need to know something specific about this summer's dangerous heat, and many of them haven't been told.
These medications work partly by affecting receptors in the brain, including in the hypothalamus, the region responsible for regulating both appetite and thirst. For many patients, the thirst-suppression effect is almost invisible day to day. In extreme heat, it can be clinically dangerous.
