Like any drugs, taking aspirin and ibuprofen in high doses for a long time can affect your health – and can be particularly harmful to your stomach.
They both belong to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used to relieve pain, reduce inflammation and to help bring down a high temperature..
According to Medline Plus, NSAIDs such as ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine.