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The Hindu
The Hindu
Technology
Sridhar Sivasubbu, Vinod Scaria

How genetics is revealing skin colour biology is more than skin-deep

Skin, with its wide spectrum of textures, hues, and histories, has long captivated the imagination of poets and storytellers. It has served as a canvas for the expression of beauty, identity, and cultural symbols. The diversity of skin colour across human populations is a product of human genetics, the migration of peoples, and the complex interplay between genes and the environment.

Together with its colour, skin opens a window into the underlying human pathophysiology, and not just because it’s the largest organ, and has as a result been the subject of many scientific and medical investigations as well. The natural colour of human skin and changes therein help clinicians diagnose a number of medical conditions. For example, genetic defects can result in the absence of pigmentation by birth, such as albinism; partial or complete depigmentation can also result in disorders like vitiligo. A number of drugs, including antimalarials and chemotherapy agents, also cause skin pigmentation.

But for all of skin’s significance and wonder, its colour has also been the basis of social hierarchies, racism, and other forms of discrimination. Recognising the biological basis of skin and celebrating the diversity of skin colour could instead foster a deeper appreciation of human differences and promote inclusivity.

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