Whatever happens between now and Everton's next game on Saturday, the starting line up will look considerably different to the one selected against Chelsea.
The injuries suffered by Ben Godfrey and Yerry Mina were two cruel blows that continue the club's centre back struggles from last season into the new campaign. Both are set for a sustained period on the sidelines, meaning two of the three starting centre backs will be unavailable for the trip to Aston Villa.
Salomon Rondon, the only recognised first team striker who is fit, will also be in contention for a start after suspension ruled him out of the season opener. Another significant difference could come in the shape of transfers, however, with the Blues landing one player and edging closer to two more.