England play Iran at the Khalifa International Stadium in their opening World Cup group fixture on Monday afternoon.
Manchester United and Manchester City have multiple players in the 26-man squad and both clubs could have representatives starting in the opening game. England made the World Cup semi-final in 2018 and they'll want to make the next step this winter.
United's Luke Shaw, Harry Maguire and Marcus Rashford have been included in the squad, while Kyle Walker, John Stones, Kalvin Phillips, Jack Grealish and Phil Foden are the Blues' representatives in Qatar.