Late-bloomer Jed Holloway will make his Wallabies debut against Argentina after being named at blindside flanker for the opening Rugby Championship Test in Mendoza.
In other notable selections by Wallabies coach Dave Rennie for the clash on Sunday (AEST), Quade Cooper takes over the No.10 jumper from Noah Lolesio and Tom Wright will start at fullback for the first time ahead of Jordan Petaia, who has been named on the wing.
Cooper missed the recent England series after injuring his calf during the warm-up for the first Test and his call-up provides a spicy sidebar after his international career was all but ended by Michael Cheika, now coach of the Pumas.
Rennie felt the experience of 34-year-old Cooper would be key in the absence of inside centre Samu Kerevi.
"Quade's trained really well, his experience, the quality of his skill set is really evident when we train as well," Rennie said.
"The impressive thing about Quade last year was we had a plan going into the game and he implemented it really well and we've got a clear plan this time as well.
"We haven't spoken about the Cheika thing at all ... his focus is on playing well for us and we expect him to do that."
Rennie said Wright's form in the Brisbane Test, when he shifted to fullback in the third minute to cover for the injured Petaia, couldn't be ignored.
"Tom was outstanding at fullback a couple of weeks ago," Rennie said.
"He's an excellent communicator, really good organiser of people around them and he's just been in really good form."
The Australians are well aware they need to front up against a Pumas pack who will be fired up by Cheika, who coached the Wallabies for five years before Rennie.
Waratahs forward Holloway was primed for his first Test cap against England but was ruled out of that series with a calf injury.
But Rennie is a big fan of the tackle-busting 29-year-old, who is equally at home in the second row.
He made a rugby resurgence this year after being initially dumped by the Waratahs in 2020 after not playing a minute during their Super Rugby AU season.
"We're really excited for him, he's such a good man and he's had a massive season for the Waratahs and deserves his chance," Rennie said.
"He's got a really good skill set, he's an excellent lineout forward and he's got a bit of an edge about him and we think that's going to be important going into the weekend."
In other changes, Folau Fainga'a will run on at hooker with Dave Porecki ruled out after suffering a head knock at training.
Lock Darcy Swain, who was red-carded and then suspended for a head-butt in the first England Test, has been recalled to partner Matt Philip ahead of Giteau's Law pick Rory Arnold.
Rennie confirmed Arnold, who has had a calf strain, would be fit for the second Test in San Juan.
Hunter Paisami and Len Ikitau will resume their centre partnership from the UK Spring tour in the absence of Kerevi.
Melbourne prop Matt Gibbon is also in line for a Test debut after being included on a bench that contains six forwards, with Jake Gordon and Reece Hodge the only backs.
Wallabies: Tom Wright, Jordan Petaia, Len Ikitau, Hunter Paisami, Marika Koroibete, Quade Cooper, Nic White, Rob Valetini, Michael Hooper (c), Jed Holloway, Matt Philip, Darcy Swain, Allan Alaalatoa, Folau Fainga'a, James Slipper. Res: Lachlan Lonergan, Matt Gibbon, Taniela Tupou, Nick Frost, Rob Leota, Pete Samu, Jake Gordon, Reece Hodge.
