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Smita S. Iyer, Associate Professor of Pathology, University of Pittsburgh

HIV enters the brain and doesn’t leave – paradoxically, drugs intended to reduce brain inflammation increase virus levels

HIV hides in reservoirs in the brain, causing persistent inflammation and long-term damage. Design Cells/iStock via Getty Images Plus

HIV can damage the brain and cause memory and cognitive problems. And once HIV enters the brain, it does not leave.

HIV targets a type of immune cell called helper T cells. These immune cells move throughout the body, including the brain, constantly scanning for pieces of foreign proteins called antigens that typically indicate the presence of a pathogen. When helper T cells detect antigens, they activate other immune cells to clear the infection.

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