Following Boris Johnson's announcement to resign as Prime Minister, Dilyn the troublemaking rescue dog will be booted out of his Number 10 home.
But his fellow feline friend, Chief Mouser Larry is staying put and will continue to reign supreme in Downing Street.
Rishi Sunak's puppy Nova has also been added to a long list of memorable politicians' pets that have been forced to exit.
Here is a look back at the history of animal residents in Downing Street, and the hilarious moments that made headlines.
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Nova
Nova the puppy arrived at Downing Street last July, when former Chancellor of the Exchequer Rishi Sunak announced her arrival.
Adorable Nova reportedly enjoyed life in Number 11 and often took naps in the Chancellor's red box and tucked into roast chicken from the kitchen.
The fox red Lab had a very short reign, and didn't have enough time to start up a mischievous reputation.
Dilyn
Dilyn the rescue dog hasn't had much longer than Nova, but he's certainly left a stamp on Downing Street.
The Jack Russell was adopted from Friends of Animals Wales by Boris Johnson and wife Carrie Symonds in 2019 and credited for sparking a surge in the breed - dubbed the 'Boris Bounce'.
Dilyn quickly became a cheeky and controversial chap, having reportedly cocked his leg over an aide's handbag, allegedly 'humped' Dominic Cummings and chewed priceless furniture and books.
Larry
Long before Dilyn stole the show, Larry the rescue cat reigned supreme in Downing Street.
Officially titled Chief Mouser to the Cabinet Office, he actually belongs to the civil servants in the Cabinet Office, who keep a voluntary kitty to buy his food.
The 15-year-old tabby (76 in humans years) has lived at Number 10 since 2011, when then-Prime Minister David Cameron adopted him from Battersea Dogs and Cats Home.
Last year, the chubby mouser was told to "cut down on treats" by vets who noticed he'd piled on lockdown pounds.
He also recently made headlines when his comical parody Twitter account announced Boris Johnson was resigning before it actually happened.
Freya
Freya the tabby cat belongs to former Chancellor of the Exchequer George Osborne.
It's safe to say her and Larry didn't always see eye to eye.
The two cats were caught fighting outside Number 10 in October 2012, leading police to intervene and break up the scrap.
Some reports even suggested David Cameron demoted Larry from his role as Chief Mouser on account of his laziness.
Freya made news again when she got lost and was found after being hit by a car over a mile away from home.
The cat with multiple lives thankfully survived then retired from her post in 2014 to the idyllic countryside of Kent.
Sybil
Sybil was the first cat in Downing Street for 10 years when she arrived with former Chancellor of the Exchequer Alistair Darling in 2007.
She had a very short stint and struggled to settle in, staying for just six months before returning to the family home in Edinburgh until her death in 2009.
Humphrey
This fluffy cat was jokingly named after Sir Humphrey from the 80s sitcom Yes Minister, and even went on to have his own five minutes of fame on the puppet show Spitting Image .
Humphrey saw both Margaret Thatcher and John Major serve as Prime Minister, then was 'reshuffled' out of the cabinet during Tony Blair's reign, as his wife was adverse to cats.
There were rumours he'd been put down, but photos later proved Humphrey was alive and well, having retired in the suburbs of south London.
Budget
Budget wasn't technically a Number 10 resident, having belonged to former Foreign Secretary Geoffrey Howe, but he was a familiar face during Margaret Thatcher's reign.
The Jack Russell was known for being taken on walks through St James' Park on the mornings of budget speeches - living up to his name.
Wilberforce
Skilled mouser Wilberforce was appointed as Office Manager's cat in 1973 and saw four Prime Ministers pass through Number 10, from Edward Heath to Margaret Thatcher.
Thatcher is even said to have bought the tabby cat a tin of sardines from a supermarket in Moscow, while on a diplomatic visit.
Wilberforce became a beloved friend of security too, as the lack of cat flap on the famed black door meant police had to ring the bell every time he wanted to go inside.
The old boy retired after 13 long years to live with a former Number 10 caretaker in the countryside, and passed away in 1988.
Peta
Peta was the first female cat to serve as Chief Mouser to the Cabinet Office. She did it for the queens - but not without sparking controversy.
Peta was said to be loud, lazy and not toilet trained. Despite some civil servants trying to get her booted out, she remained in the position before quietly retiring in 1976.
Original mousers
Before Peta, there were numerous Chief Mousers who made their names at Downing Street.
Peter III had quite the international fanbase, from Italy to the US, after appearing on the BBC in 1958.
Nelson was also a popular pet, known for secretly eating smoked salmon from Sir Winston Churchill's plate at the dinner table, when wife Clementine wasn't looking.
Though Nelson is said to have had a rocky relationship with his feline rival, Munich Mouser.
Prior to catty Munich Mouser, Peter the black cat was the second feline to be designated mouser - but is often seen as the first, as his predecessor Treasury Bill didn't have an official title.
Old top dogs
Only a few dogs date back to the 1940s, with Winston Churchill's beloved Rufus being one of them.
Rufus was a fixture at 10 Downing Street through the war years and even accompanied the Prime Minister on a visit to Buckingham Palace.
Churchill was heartbroken when Rufus was killed by a car in October 1947, though soon replaced him with Rufus II (but the II was 'silent').
Before Rufus and Rufus II, Ting the Airedale terrier lived alongside Clement Attlee and his family.
They also owned a pet goal named Mary who sadly wasn't allowed to live at Number 10, and instead resided at the family's home in Stanmore.
Do you remember any of these memorable moments? Let us know in the comments below.
