Berlin: Researchers in Michael Sigal's lab at the Max Delbruck Center and Charite - Universitatsmedizin Berlin have discovered the significance of the p53 gene in ulcerative colitis. The work, published in Science Advances, proposes a potential new therapeutic target for preventing illness progression to cancer.
A team of researchers led by Kimberly Hartl, a graduate student at the Berlin Institute for Medical Systems Biology of the Max Delbruck Center (MDC-BIMSB) and Charite - Universitatsmedizin, have shed new light on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis (UC) - an inflammatory bowel disease that afflicts an estimated five million people worldwide and that is linked to an increased risk of colon cancer. The research points to a new way to stop the disease from progressing. The study was published in the journal Science Advances.
