The Duke and Duchess are to take over the running of their Archewell company after a senior aide stepped down from her role.
Mandana Dayani has announced she is leaving her post as president.
A spokesman for Harry and Meghan said they will now take “full lead” of their Archewell media and charitable foundation and Ms Dayani’s role will not be replaced.
It is believed that Ms Dayani, 40, has been at the helm of the couple’s media and charitable empire for less than 18 months.
She ran the day-to-day operations. Ms Dayani’s departure comes after a trailer promoting the couple’s Netflix docuseries was released on Thursday.