The Joe Gibbs Racing driver was battling up around the top-five late in the race when Chastain came up the track and made contact with the left-rear of the No. 11 car, sending Hamlin spinning.
Chastain went on to place second, very nearly taking the lead from Chase Elliott before the race-ending caution. Hamlin, who sustained even more damage in a later wreck, finished 25th.