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WhatToWatch
WhatToWatch
Entertainment
Terrell Smith

Grey’s Anatomy season 22: release date, cast and everything we know about the long-running medical drama

Chandra Wilson Ellen Pompeo
Chandra Wilson smiling in a green shirt in Grey's Anatomy season 19.

TV’s longest-running medical drama is back for another surgical rotation in the Fall 2025-2026 TV season, with Grey's Anatomy season 22 hitting the airwaves.

After a traumatic Grey's Anatomy season 21 finale (which is almost par for the course at this point), there appear to a few changes on the horizon. We're talking romance shifts, life-or-death medical emergencies for the staff and your usual Grey's heartbreaking moments.

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