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Entertainment
Terrell Smith

Grey’s Anatomy season 21: next episode info, trailer, cast and everything we know about the long-running medical drama

Caterina Scorsone and Ellen Pompeo as Amelia and Meredith talking in an office in Grey's Anatomy season 21.

TV’s longest-running medical drama in primetime returns for more tear-jerking moments and intriguing storylines with Grey's Anatomy season 21. 

The series continued to captivate fans in season 20, and while season 21 will of course include many things that are familiar, there will be some noticeable changes. We're talking cast departures and even a brand-new showtime. Curious as to what we mean? 

Here's everything we know about Grey's Anatomy season 21. 

Next episode of Grey’s Anatomy season 21

Grey's Anatomy is currently on a break for the duration of 2024. The midseason premiere, showcasing the rest of season 21, doesn't kick off until March 6, 2025, at 10 pm ET/PT on ABC. Now is a great time to catch up with anything you've missed this season on Hulu.

Grey’s Anatomy is an ABC original series and as such, new episodes air live directly on the broadcast network. For those that have cut ties with traditional cable/satellite television, ABC is available to stream on live TV streaming services such as Fubo TV, Hulu with Live TV and YouTube TV.  New episodes of the season become available to stream the next day on Hulu. 

In the UK, season 20 episodes are expected to stream on Disney Plus

Grey’s Anatomy season 21 cast

Kim Raver and James Pickens Jr., Grey's Anatomy (Image credit: ABC/Eric McCandless)

First things first, in some casting departure news, Midori Francis is exiting the role of intern Mika Yasuda. Additionally, Jake Borelli is set to part ways with his character Levi Schmitt, but Deadline states his exit won't actually happen until early into season 21. 

With all of that being said, it's expected that the rest of the main cast will remain the same at this point. However, again according to Deadline, budget cuts will impact the cast as veteran players are being guaranteed fewer episodes. That translates to the likelihood that you'll see a little less of your favorite characters. 

Here is the anticipated cast of series regulars: 

  • Chandra Wilson as Dr. Miranda Bailey
  • James Pickens Jr. as Dr. Richard Webber
  • Kevin McKidd (Brave) as Dr. Owen Hunt   
  • Kim Raver (24) as Dr. Teddy Altman   
  • Camilla Luddington (True Blood) as Dr. Jo Wilson   
  • Caterina Scorsone (Private Practice) as Dr. Amelia Shepherd   
  • Chris Carmack (Nashville) as Dr. Atticus Lincoln       
  • Anthony Hill (This Is Us) as Dr. Winston Ndugu     
  • Adelaide Kane (Once Upon a Time) as Dr. Jules Millin 
  • Harry Shum Jr. (Glee)  as Dr. Benson Kwan   
  • Alexis Floyd (Inventing Anna) as Dr. Simone Griffith
  • Niko Terho (The Thing About Harry) as Dr. Lucas Adams
  • Scott Speedman (Animal Kingdom) as Dr. Nick Marsh 

Now according to Deadline, Ellen Pompeo is expected to appear in at least seven episodes this season, which is great news for longtime fans of the show. 

Grey’s Anatomy plot

Here is a synopsis of the original series:

"Recipient of the 2007 Golden Globe Award for Best Drama Television Series and nominated for multiple Emmys, including Outstanding Drama Series, Grey’s Anatomy is considered one of the great television shows of our time. The high-intensity medical drama... follows a team of doctors at Grey Sloan Memorial who are faced with life-or death decisions on a daily basis. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white."

Grey’s Anatomy season 21 trailer

Here's a trailer for the new season. 

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