Spoiler alert! This story contains major spoilers for the first two episodes of Grey’s Anatomy Season 22. They can be streamed with a Hulu subscription if you need to catch up.
Grey’s Anatomy hit a pretty impressive milestone Thursday night on the 2025 TV schedule, celebrating its 450th episode. “We Built This City” paid homage to past eras of the medical drama with several references to past seasons and another of its signature gnarly medical cases. We also saw a couple of familiar faces return, including Kelly McCreary, whose character Maggie was involved in a twist that has meaningful real-life connections to writer Zoanne Clack and creator Shonda Rhimes.
