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The Guardian - UK

Science

Andrew Gregory Health editor

Genetics may help explain why results from weight-loss jabs vary, say scientists

Wegovy medicine with injectors — Weight-loss drugs such as Wegovy help regulate appetite, insulin release and digestion – but they may not work as well for everyone. Photograph: James Manning/PA

Scientists have discovered how genetics may help explain why weight-loss jabs work better for some people than others.

Variations in two genes involved in gut hormone pathways, which regulate appetite and digestion, may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines.

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