The United Nations Environment Programme recently published a scientific review that looks at environmental threats and risks in light of the COVID pandemic. It analyses links between human infectious diseases and nature and what we know about how diseases (zoonoses) can transfer from animals to humans.
The report (which I wrote) argues laboratory procedures (including “gain of function” research) should be recognised as one potential driver of zoonotic “spillover”.
The term “gain of function” applies to the functional consequences of changes in the genetic makeup of an organism, including viruses. Such changes can be harmless, or even beneficial. They can occur naturally, when organisms mutate and evolve.