It's just 9.5 miles long but it feels like quite an adventure.
Once named Britain's busiest bus route - with nearly 10 million passengers a year - it's so Mancunian it's been immortalised in song.
It's been the scene of bus wars - with competing companies flooding the tarmac with vehicles in a desperate fight for passengers - and it stretches from suburban Hazel Grove all the way up to town.