Club captain Seamus Coleman, new signing Amadou Onana and midfielder Allan could all make their first starts of the season as Everton visit Fleetwood in the Carabao Cup.
Frank Lampard is expected to use the tie to give valuable first team minutes to a number of players building match fitness after disrupted pre-seasons. They include Coleman, who is yet to play following surgery over the summer.
The 33-year-old travelled with the first team squad to the US for the club's pre-season tour but his only minutes since the end of last season have come for the Under-21s.