FDA Approves Needle-Free Nasal Spray For Severe Allergic Reactions

A sign informs customers that Narcan nasal spray will soon be sold over-the-counter without a prescription, at a drug store in Somerville

The US Food and Drug Administration has given the green light to the first nasal spray epinephrine drug, Neffy, for the treatment of severe allergic reactions known as anaphylaxis. This approval provides a needle-free alternative to traditional EpiPens and similar medications, offering a more convenient option for adults and children weighing over 66 pounds.

Neffy is administered as a single dose sprayed into one nostril, with the option for a second dose if necessary. Studies have shown that Neffy provides comparable levels of epinephrine in the blood, as well as similar increases in blood pressure and heart rate, to injectable epinephrine.