Arsenal, 14-times winners of the FA Cup, will face eight-times champions Liverpool in a blockbuster third-round clash in January, while bitter rivals Newcastle United and Sunderland face off at the Stadium of Light.
Holders Manchester City face Huddersfield Town, while last season's losing finalists Manchester United take on 2013 champions Wigan Athletic.
In other all-Premier League draws, Tottenham Hotspur will host Burnley, Crystal Palace are at home to Everton and Brentford face Wolverhampton Wanderers.
The matches will be played across January 5-8.