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The Hindu
The Hindu
Technology
Priyali Prakash

Explained | The research in click and bioorthogonal chemistry that led to the 2022 Nobel Prize in the field

The story so far: The 2022 Nobel Prize in Chemistry has been awarded to chemists Carolyn R. Bertozzi and K. Barry Sharpless from the U.S., and Morten Meldal from Denmark, for their work in the field of click chemistry and bioorthogonal chemistry.

Dr. Sharpless was the first scientist to work on what is today called click chemistry – a branch of science that explores the assembly of molecules. In fact, this is not his first Nobel Prize in Chemistry. He previously won the award in 2001.

Soon after, Dr. Meldal and Dr. Sharpless – independently of each other – presented the copper-catalysed azide-alkyne cycloaddition (CuAAC), a reaction that is now widely used in fields like medicinal chemistry.

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