Yerry Mina and Mason Holgate are set to start for Everton as Michael Keane drops to the bench after his last-minute call-up to the starting eleven at Liverpool last week.
Mina, rested at Anfield, was always expected to return as Frank Lampard manages his recovery from injury.
Dominic Calvert-Lewin is back in the matchday squad, as revealed by Lampard on Friday, but he starts on the bench - where there is also a surprise spot for Tom Davies.
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Fabian Delph returns but he will partner Abdoulaye Doucoure, with Allan dropping to the bench.
Richarlison, who scored the late equaliser as Everton earned a draw against Leicester City last time they played at Goodison Park, looks set to lead the front line, supported by Anthony Gordon and Alex Iwobi and Demarai Gray - just like how the Blues began in the Merseyside derby.
Davies, pictured returning to training this week after an injury that was expected to leave him out of action for the rest of the season, is a surprise inclusion on the bench. He was not registered in the Premier League squad at the end of the January transfer window but was allowed to return when Jean-Phillipe Gbamin left on loan.
Starting XI: Pickford, Coleman, Mykolenko, Holgate, Mina, Iwobi, Doucoure, Delph, Richarlison, Gray, Gordon.
Subs: Begovic, Kenny, Keane, Allan, Calvert-Lewin, Daves, Branthwaite, Rondon, Alli.
Chelsea: Mendy; Azpilicueta, Silva, Rudiger; James, Jorginho, Loftus-Cheek, Alonso; Mount, Werner, Havertz.
