Manchester United have reached the last 16 of the Europa League in each of the six occasions that they have competed in UEFA's second-tier competition.
Italian giants AC Milan were their most recent opponents at this stage of the 2020/21 edition and were narrowly beaten 2-1 by Ole Gunnar Solskjaer's side on aggregate. United have also previously played Spanish opposition in this round before, back when they were knocked out against Marcelo Bielsa's Athletic Club in 2012.
Much has changed rule-wise over those 11 years, though, and even since Solskjaer's side reached the 2021 final, so the Manchester Evening News have recapped the competition's ever-changing rules before kick-off.
