Wales head coach Ioan Cunningham has made five changes to the side which has started their Six Nations campaign with back-to-back wins.
His side, unchanged up until now after they came from behind to win against both Ireland and Scotland, now face reigning champions England at Gloucester's Kingsholm on Saturday (4.45pm kick-off, live on BBC Two).
Donna Rose starts at loosehead prop after an impressive display off the bench against Ireland where she scored two tries. Sisilia Tuipulotu has been handed her first international start at lock. In the back-row, Sioned Harries - player of the match and try-scorer against Scotland - comes in at No. 8 after two strong cameos off the bench, meaning captain Siwan Lillicrap moves over to the blindside flank and Alisha Butchers shifting to openside flanker. Robyn Wilkins and Ffion Lewis, who sealed Wales' win last time out with a 76th-minute try, are the starting half-backs as Elinor Snowsill and Keira Bevan are named on the bench.