New England head coach Steve Borthwick has axed senior stars Billy Vunipola, Jonny May and Jack Nowell in his first Six Nations squad.
It's a bold and significant move from the new coach as he sets his stall out in the wake of Eddie Jones' departure.
Number eight Vunipola and wings May and Nowell were all involved in the 27-13 defeat by South Africa that concluded the autumn and spelt the end of the Jones era.
While the trio are not part of the 36-man squad that will next week begin preparations for the Six Nations opener against Scotland on February 4, there are recalls for Dan Cole and Elliot Daly.
Cole was dropped by England after the 2019 World Cup final while Daly has been frozen out since last year's Six Nations despite his superb form for Saracens.
Northampton's rookie fly-half Fin Smith is present for the first time, providing cover for Owen Farrell and Marcus Smith, while Ollie Hassell-Collins, George McGuigan, Cadan Murley and Jack Walker are the other uncapped players.
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England Six Nations squad
Forwards: Ollie Chessum, Dan Cole, Ben Curry, Alex Dombrandt, Ben Earl, Ellis Genge, Jamie George, Joe Heyes, Jonny Hill, Nick Isiekwe, Maro Itoje, Courtney Lawes, Lewis Ludlam, George McGuigan, Bevan Rodd, Sam Simmonds, Kyle Sinckler, Mako Vunipola, Jack Walker, Jack Willis.
Backs: Elliot Daly, Owen Farrell, Tommy Freeman, Ollie Hassell-Collins, Dan Kelly, Max Malins, Joe Marchant, Alex Mitchell, Cadan Murley, Henry Slade, Fin Smith, Marcus Smith, Freddie Steward, Manu Tuilagi, Jack van Poortvliet, Ben Youngs.
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