Eddie Jones has already had to contend with a few major setbacks since announcing his Six Nations squad, and the England coach is prepared for any vaccine -related changes to come during the tournament.
Current Covid-19 restrictions in Great Britain and Ireland mean unvaccinated players still have a chance to feature, but that won't be the case for games in France and Italy.
The vaccine pass systems in those countries mean even professional athletes aren't exempt from regulations, demanding anyone entering public venues like stadia must be double-jabbed.