Dolce & Gabbana is to drop the use of animal fur across its collections.
The Italian luxury fashion house said its transition to an eco-friendly faux alternative will begin this year.
It joins other brands – including Armani, Gucci, Prada and Moncler – in adhering to guidelines set by the Fur Free Alliance (FFA), a global network of animal rights groups.
"Dolce & Gabbana is working toward a more sustainable future that can't contemplate the use of animal fur", the company said in a statement.
"The entire fashion system has a significant social responsibility role that must be promoted and encouraged."
Around 100 million animals are raised and killed for their fur every year globally, according to the FFA.
It said the use of battery cages leads to stress-related welfare problems and methods of preserving pelts, such as gassing and head-to-tail electrocution, cause severe pain and distress.
FFA chair Joh Vinding said: "We celebrate Dolce & Gabbana for ending its association with fur cruelty and transitioning to more humane and innovative materials.
"The world is changing and brands like Dolce & Gabbana are rightly adapting to an evolving consumer, one that wants companies to take a stand against animal cruelty and innovate for a more sustainable future."
In December, Italian authorities voted to ban the breeding of animals for fur – including mink, foxes and chinchillas – and close all active fur farms by the end of June.
Italy joins a group of 20 countries, including the UK, that have either banned or limited fur farming over the last two decades.
PJ Smith, fashion policy director at the Humane Society of the United States and Humane Society International, said: "Ending the use of fur creates a higher standard for what is acceptable in fashion".
Dolce & Gabbana was founded in 1985 by Domenico Dolce and Stefano Gabbana. It is currently headquartered in Milan.
The company already sells a number of faux fur products, although clothing featuring animal fur is still available for purchase on its website. A double-breasted cashmere coat with fox fur collar, for example, retails at £5,450.
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