Asylum seekers have become sick with diphtheria while staying at a hotel in the UK, according to officials.
A "small number" of cases were confirmed at an accommodation provided by the Home Office in Humber, with some people needing medical treatment.
It comes after updated figures were published by the UK Health Security Agency (UKHSA) on Tuesday, showing the total number of cases for the year so far stands at 67.
Five cases of diphtheria among asylum seekers were reported between December 12 and 18. In the previous week, the total was 62 after another five cases were reported.
This time last month - between November 14 and 20 - the number was 45.
A Home Office spokesperson told the BBC : "We are aware of reports of some people requiring health interventions at accommodation being provided in the Humber area.
"Home Office and UKHSA officials are working with the local services and the accommodation provider to offer all the appropriate support measures."
Diphtheria is a highly contagious infection that affects the nose and throat, and sometimes the skin. It's spread by coughs and sneezes, or through close contact with someone who is infected.
In the UK, uptake for diphtheria vaccinations is high, as it is included in the 6-in-1 doses given to babies at eight, 12 and 16 weeks of age, and then again at 3 years and four months in the 4-in-1 pre-school booster.
The risk posed to the wider public remains "very low", said the UKHSA.
In a statement, the health body said: "Whilst we continue to see a very small number of diphtheria cases amongst asylum seekers in the region, the risk of diphtheria to the wider public remains very low as there is a high uptake of the diphtheria vaccine in this country."
According to the latest UKHSA report, 50 of the cases were recorded in the South East, six were in London, and there were fewer than five in each of the following areas: East of England, West Midlands, South West, North East, North West and Yorkshire and the Humber.
No breakdown by county has been provided.
Last month, a 31-year-old asylum seeker who tested positive for diphtheria died at a hospital in Kent.
Hussein Haseeb Ahmed passed away at the Queen Elizabeth the Queen Mother (QEQM) hospital on November 19 after being held at Manston after crossing the Channel a week earlier.
The Home Office initially said there was no evidence he died from an infectious disease but a follow-up test for diphtheria was positive, indicating this may have been the cause.
An inquest into Mr Ahmed's death has been adjourned until next May.
The latest report comes after the Home Office told a group of migrants they would be moved from a London hotel to military barracks in Kent, prompting a protest, with a local MP saying the decision was causing "huge distress" days before Christmas.
In November, the immigration minister told MPs asylum seekers with symptoms of diphtheria would be put into isolation after the UKHSA said there has been an "increase" in the number of infections among those coming to the UK.
Robert Jenrick said migrants showing signs of the highly-contagious disease will be separated for a "short period" at the Manston migrant processing centre near Ramsgate or held in a "designated isolation centre" while they are treated.
Any asylum seekers who may have the infection but are already in hotels will be told to isolate in their rooms while they are treated.
Home Secretary Suella Braverman faced criticism about overcrowding and outbreaks of disease at Manston amid concerns a man held there may have died from a diphtheria infection.
Ministers and health officials have insisted the risk of the public getting diphtheria is very low and infections are rare.
The illness - which affects the nose, throat and sometimes skin - can be fatal if not treated quickly but antibiotics and other medicines are available.
Some public health experts raised concerns about the spread of the disease as migrants were moved to hotels.
A Home Office spokesperson said: "We take both the welfare of those in our care and our wider public health responsibilities extremely seriously.
"As such, we continue to work closely with the NHS and UK Health Security Agency to support individuals affected and limit transmission of diphtheria.
"UKHSA has previously indicated that cases are most likely to have become infected before they arrived in the UK.
"We are offering diphtheria vaccinations to people at Manston, which has 24/7 health facilities and trained medical staff."
