A large new analysis has sorted popular longevity interventions into the ones that measurably shifted biological aging markers and the ones that did not, and over-the-counter supplements landed on the wrong side of that line.
Researchers pooled data from 51 intervention studies and applied the same standardized panel of 16 epigenetic clocks plus 94 additional DNA methylation biomarkers to each one, covering more than 3,000 samples. The work was published in Nature Medicine. Healthy diets and regular exercise reduced epigenetic aging measures. Three classes of prescription drugs produced the largest average effects. Supplements produced limited and inconsistent evidence.
