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LiveScience
LiveScience
Mindy Weisberger

Diagnostic dilemma: A brain lesion gave a woman a lifetime of joyless laughing fits

A close-up blurry photo of a woman laughing.

The patient: A 31-year-old woman

The symptoms: The woman visited a clinic because she had long experienced bursts of uncontrollable laughter, which doctors described as "mirthless" in a report of her case. According to the patient, she had been having these intermittent bursts of involuntary laughter since infancy, but her condition had never been formally investigated or diagnosed.

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