Q: Which is considered to be the rarest disease in the world?
A: RPI Deficiency. The lack of Ribose-5-Phosphate Isomerase (RPI), a crucial enzyme, can cause muscle stiffness, seizures, and reduction of white matter in the brain. The only known patient was diagnosed in 1984.
Q: The movie Paa, starring father and son duo Amitabh Bacchhan and his son Abhishek, in a role reversal situation, has a plot built on a rare disease. Do you know what it is?
