There can be a way back.
There doesn't appear to be many more significant signs of disrespect that a player can show to a manager than refusing to be substituted on. It's been seen on several occasions in recent years - Carlos Tevez for Manchester City being a notable example - and it understandably sends many managers into a frothing rage.
Erik ten Hag handled the situation markedly different when he was given the sour dish by Cristiano Ronaldo. So much so that it wasn't even obvious that Ronaldo had refused to play. Instead, it seemed likely that he had walked off in a strop before the final whistle because he hadn't been brought on.