A couple died after the husband stabbed his wife, then fatally stepped in front of a truck, killing himself.
Jason and Jessica Wray, both 45 years old, of Madison, Wisconsin have three children and were identified by their family and friends.
Madison Police Chief Shon Barnes said it was reported that someone in the home had died on Sunday afternoon.
Police rushed to the scene and said it was apparent the victim had been "violently and physically attacked."
Ambulances at the scene tried to save Ms Wray's life but she was declared dead at the property.
As police were trying to locate the victim's husband, who they determined was the main suspect, they were informed that a man on foot had been hit by a vehicle but then got back into his car and drove to the motorway, according to Chief Barnes.
On the motorway, he once again got out of his vehicle and stepped in front of a truck, Mr Barnes said.
He was pronounced dead on the scene and later identified as Ms Wray's husband.
The collision occurred at around 3:36 pm in the west lanes of the interstate near Buckeye Road, State Patrol Sargeant Jason Holtz said in a statement.
The pair were both doctors assistants at the University of Wisconsin-Madison Health and graduated from the University of Iowa, according to their UW Health pages.
Police have declined to confirm details about their personal life but photos on Ms Wray's Facebook page show the couple with three young children.
It was unclear if the children were home at the time of the attack.
A Go-Fund-Me has also been set up by a neighbour to help with funeral costs.
"We would love to be able to gather additional funds to support the kids in many ways. These kids are surrounded by so much love but growing up after losing both parents will take a lot more. I, along with my husband and other neighbours, organised this fund", the page says.
At a police briefing, Mr Barnes urged people in abusive relationships to contact police or others for help, as they are taking this as a line of enquiry.
"If you are a victim of domestic violence or you know someone who you think may be a victim of domestic violence — we have to take these seriously," Barnes said.
