Conor Murray's Autumn series is over after it was confirmed the first half groin injury he suffered in the victory over South Africa has ruled him out for several weeks.
And Ciarán Frawley's hopes of a debut Test appearance in Saturday's Aviva Stadium clash with Fiji (1pm) have been dashed as the IRFU said he suffered a twisted knee in last Friday night's Ireland A loss to the All Blacks XV.
Murray - who started on his 100th appearance for Ireland but only lasted 27 minutes after suffering the injury when he made a break - and Frawley have returned to Munster and Leinster respectively to continue their rehab ahead of next month's opening Champions Cup fixtures.