Bukayo Saka returns to the Arsenal line-up for the biggest North London Derby in over a decade. The Gunners can secure Champions League football next season with a win against their arch-rivals.
Saka is back from injury while Ben White is named among the substitutes, with Eddie Nketiah continuing upfront after a rich vein of form.
Cedric Soares starts at right back again with Takehiro Tomiyasu filling in for the injured Kieran Tierney at left-back.
READ MORE: Tottenham vs Arsenal LIVE - All the action from the North London Derby
In midfield, Mohamed Elneny partners Granit Xhaka while Martin Odegaard, Saka and Gabriel Martinelli supporter Nketiah in attack.
Mikel Arteta has named a strong substitutes bench with the likes of Nicolas Pepe, Emile Smith Rowe and Alexandre Lacazette all available for the Spaniard to choose from if needed.
Arsenal XI: Ramsdale, Cedric, Gabriel, Holding, Tomiyasu, Elneny, Xhaka, Odegaard, Martinelli, Saka, Nketiah.
Subs: Leno, Tavares, Swanson, White, Sambi Lokonga, Patino, Smith Rowe, Pepe, Lacazette