Arsenal have been boosted with both Ben White and Gabriel Magalhaes passed fit to start against Newcastle. The Gunners can secure qualification for the Champions League if they win their final two games of the season at St James' Park and Everton next week.
Nuno Tavares has been given a chance to impress at left back with Cedric Soares dropping to the bench, with Takehiro Tomiyasu returning to his natural position of right back.
Granit Xhaka partners Mohamed Elneny in central midfield, while Martin Odegaard, Emile Smith Rowe and Bukayo Saka support the in-form Eddie Nketiah upfront.
The Gunners have several attacking options to choose from on the bench, with Gabriel Martinelli, Nicolas Pepe and Alexandre Lacazette all available.
Mikel Arteta has called up Arsenal's highly-rated youngsters including Salah Oulad M'Hand, Charlie Patino and Zak Swanson, who all take their place among tonight's substitutes.
Arsenal XI: Ramsdale, Tomiyasu, Gabriel, White, Tavares, Elneny, Xhaka, Odegaard, Smith Rowe, Saka, Nketiah.
Subs: Leno, Cedric, Swanson, Oulad M'Hand, Lokonga, Patino, Martinelli, Pepe, Lacazette.