The Kansas City Chiefs’ 2022 NFL season kicks off with a matchup against the Arizona Cardinals.
The Chiefs have a 9-3-1 career record against the Cardinals. This game marks the first time the two teams have played in the regular season since 2018. Who will come out on top in Week 1 of the 2022 regular season?
Below are important game details about this preseason matchup. If you have questions about the game, reach out to us on Twitter @TheChiefsWire.
Game information:
Who: Kansas City Chiefs vs. Arizona Cardinals
When: Sunday, Sept. 11, 3:25 p.m. CT
Where: State Farm Stadium – Glendale, Arizona
Streaming:
In-market live stream: fuboTV (free 7-day trial)
Broadcast:
Radio: WDAF-FM (106.5FM Kansas City)
Broadcasters:
Tony Romo, Jim Nantz and Tracy Wolfson
Referee:
Opponent wire site:
2022 Schedule:
| Week | Date | Opponent | Time | |
| 1 | Sunday, Sept. 11 | @ Arizona Cardinals | 3:25 p.m. CT on CBS | Tickets |
| 2 | Thursday, Sept. 15 | vs Los Angeles Chargers (TNF) | 7:15 p.m. CT on Amazon Prime Video | Tickets |
| 3 | Sunday, Sept. 25 | @ Indianapolis Colts | Noon CT on CBS | Tickets |
| 4 | Sunday, Oct. 2 | @ Tampa Bay Buccaneers (SNF) | 7:30 p.m. CT on NBC | Tickets |
| 5 | Monday, Oct. 10 | vs. Las Vegas Raiders (MNF) | 7:15 p.m CT on ESPN | Tickets |
| 6 | Sunday, Oct. 16 | vs. Buffalo Bills | 3:25 p.m. CT on CBS | Tickets |
| 7 | Sunday, Oct. 23 | @ San Francisco 49ers | 3:25 p.m. CT on FOX | Tickets |
| 8 | Sunday, Oct. 30 | BYE | BYE | BYE |
| 9 | Sunday, Nov. 6 | vs. Tennessee Titans (SNF) | 7:20 p.m. CT on NBC | Tickets |
| 10 | Sunday, Nov. 13 | vs. Jacksonville Jaguars | Noon CT on CBS | Tickets |
| 11 | Sunday, Nov. 20 | @ Los Angeles Chargers | 3:25 p.m. CT on CBS | Tickets |
| 12 | Sunday, Nov. 27 | vs. Los Angeles Rams | 3:25 p.m. CT on FOX | Tickets |
| 13 | Sunday, Dec. 4 | @ Cincinnati Bengals | 3:25 p.m. CT on CBS | Tickets |
| 14 | Sunday, Dec. 11 | @ Denver Broncos (SNF) | 7:20 p.m. CT on NBC | Tickets |
| 15 | Sunday, Dec. 18 | @ Houston Texans | Noon CT on CBS | Tickets |
| 16 | Saturday, Dec. 24 | vs. Seattle Seahawks | Noon CT on FOX | Tickets |
| 17 | Sunday, Jan. 1 | vs. Denver Broncos | Noon CT on CBS | Tickets |
| 18 | Saturday / Sunday, Jan. 7 or 8 | @ Las Vegas Raiders | TBD CT on TBD | Tickets |
Betting:
NFL odds courtesy of Tipico Sportsbook. Odds updated Saturday at 2:22 PM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: Chiefs (-6)
- Moneyline: Chiefs (-253), Cardinals (+207)
- Total: 53.5 Points
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