Chelsea have been drawn away to Luton Town in the FA Cup fifth round while Manchester City will visit Peterborough, as many of the big Premier League teams were kept apart.
The Blues needed late penalty heroics from goalkeeper Kepa Arrizabalaga to edge past Plymouth Argyle at Stamford Bridge, and face a trip to Luton after they ended Cambridge’s run.
Peterborough, also of the Championship, defeated QPR and will host Premier League leaders City after Pep Guardiola’s side brushed aside Fulham at the Etihad Stadium.
Middlesbrough's reward for their penalty shoot-out victory over Manchester United on Friday is a home tie against Antonio Conte’s Tottenham.
Southampton’s home fixture against West Ham is one of two confirmed all-Premier League clashes, with Liverpool vs Norwich the other.
Boreham Wood, who stunningly knocked out Bournemouth on Sunday night in the shock of the round, now face a trip to Goodison Park and Frank Lampard’s Everton.
FA Cup Fifth Round draw
Luton Town vs Chelsea
Crystal Palace vs Stoke City
Peterborough vs Manchester City
Liverpool vs Norwich
Southampton vs West Ham
Middlesbrough vs Tottenham
Nottingham Forest vs Huddersfield Town
Everton vs Boreham Wood