Killed tech exec Bob Lee made repeated attempts to flag down passing cars before collapsing in the street and dying.
He was seen in CCTV footage staggering in the final moments before collapsing to the ground.
Police rushed to the scene after the victim himself called 911 but he couldn't be saved.
In the footage Mr Lee, mortally wounded, can be seen stepping in front of a car and pleading for assistance.
Despite the desperate plea for help the driver of the unidentified red vehicle drives away. The victim then stumbles to an apartment building before collapsing backwards onto the sidewalk.
He lies motionless for a few moments before pulling himself to his feet. Before getting up he tries to flag down another car with an outstretched hand covered in blood.
This second car also drives away.
Lee can be seen carrying himself away clutching his chest, leaving clear spatters of blood on the sidewalk.
Mr Lee, a dad to two young daughters, had reportedly returned to San Francisco from Miami for a “quick visit” and stayed an extra day, according to friends.
The tech chief was known affectionately as "Crazy Bob" and had launched the Cash App, which has tens of millions of users in the US and the UK.
In a call made by the female dispatcher to officers, relaying Mr Lee's situation to emergency services, she can be heard saying: “There’s a male screaming ‘help,’ saying ‘someone stabbed me.”
While sharing the location of the victim, she said: “Advised he is bleeding out."
She later added: "He’s outside on the street.”
Lee, 43, was seen on the phone to 911 at about 2.30am on Tuesday, after he was stabbed in the chest twice.
He was also the chief product officer of San Francisco-based cryptocurrency startup MobileCoin and an investor in SpaceX, Clubhouse, and Figma.
Mr Lee had been a part of the Bay Area software development community for a long time and had recently moved to Miami.
San Francisco Police Department Chief Bill Scott refused to confirm if the mugging was random; the CCTV of which was seen by the San Francisco Standard.
No arrests have been made.
Chief Bill Scott said: "I have nothing to share yet. We don’t want to be premature and definitely we don’t want to speculate. So we are going to be thoughtful about following the evidence and we’ll put out what we’ll put out as soon as we can.”
Mr Lee's death has caused an outcry with many concerned over the state of public safety in San Francisco.
Tech chief Elon Musk has spoken out against Mr Lee's death as he asked what San Francisco district attorney Brooke Jenkins is doing to "incarcerate repeated violent offenders".
