Carlton will be forced to fight for their season without Charlie Curnow and Harry McKay, with the star forwards headlining six forced changes following a day of Blues carnage at the MCG.
Curnow (ankle) and McKay (quad) will be sidelined for Sunday's must-win match against West Coast at Optus Stadium.
The pair have been listed as missing one-to-two weeks, meaning they are every chance to be out for the rest of the home-and-away season.
Defenders Adam Saad (hamstring) and Jordan Boyd (adductor), and forwards Jack Martin (hamstring) and Lachie Fogarty (collarbone) were also injured during Sunday's disastrous 74-point smashing by Hawthorn.
Boyd and Fogarty have been ruled out for the rest of the season, while Saad and Martin will be out for up to two weeks, like McKay and Curnow.
Tom De Koning (foot/lung), Adam Cerra (hamstring), Orazio Fantasia (calf) and Matt Cottrell (shoulder) were already missing from the Blues' first-choice team.
Blues coach Michael Voss will have to get creative to fill the holes of Curnow and McKay, who have shared the last three Coleman medals between them.
Curnow's injury means he will be denied the chance to become the first forward since Gary Ablett Snr (1993-95) to win three-straight Coleman medals.
The 27-year-old entered the clash with the Hawks under an injury cloud, failing to finish the match.
Star defender Jacob Weitering believes the Blues let their fans down in capitulating to Hawthorn.
The Blues vice-captain admitted it was a tough review of their fifth loss in six games.
"Disappointing is probably the way to look at it," Weitering said on Tuesday before Carlton's injury report was released.
"Certainly lost some connection. There wasn't a whole lot of communication (on the ground).
"There was some honest conversations about what we can do better as individuals, as line groups, and as a team.
"It's certainly not the way we play our football.
"And I guess, in a sense, we certainly let ourselves down, the fans, and we've got a massive opportunity to make it right this week."
As difficult as the loss was to take, Weitering urged for calm.
If Carlton win their last two games against West Coast (away) and St Kilda (Marvel Stadium), they can still play finals for the second-straight season.
Three weeks ago the Blues were sitting second and seemed destined to secure a top-four finish for the first time since 2000.
During the middle of last season Carlton slumped to 4-1-8 and they memorably surged home to make a preliminary final.
"Last year everyone was saying blow the place up again," he said.
"They were calling for Vossy's (Blues coach Michael Voss) head halfway through and saw what happened.
"Our best is certainly good enough if we play the right way."
