They can sell for up to £3,000 - but have been put up for adoption with the RSPCA for just their adoption fee.
Four Cane Corso puppies, both males and females, have begun their search for new homes after arriving at the RSPCA's Laybourne Animal Centre.
Due to being under three-months-old, the puppies need owners who spend most of their time at home and can help them with on their training and socialisation skills.
A statement reads: "We currently have four Cane Corso puppies looking for homes.
"They will require homes with a secure private gardens to help with their house training and allow them space to play and run about.
"Ideally, we are looking for homes where there has been previous experience with large breed dogs and/or knowledge of the breed and their characteristics and we would also suggesting researching the breed and looking into insurance."
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The Cane Corso is an Italian breed of mastiff who love having a job to do around the house - as they were used for hunting large game and herding cattle in the past.
Adult males usually stand at 25 to 27.5 inches at the withers, with females between 23.5 and 26 inches. Their weight typically ranges from 90 to 120 pounds.
They have been described as a "highly intelligent" breed who can be extremely docile and affectionate towards humans, especially children.
Breeders sell Cane Corsos for between £500 and £3,000 online, depending on their age and whether they're a pedigree.
The statement adds: "They would suit a home with secondary school age children (12 years and older) and may be OK to live with existing cats and dogs providing they are given time and space to get to know one another."
The RSPCA is urging people to turn to adoption centres rather than breeders when wanting to welcome a new pet into their home.
"While it may be easy to find animals on the internet or even spend hundreds on an expensive breeder, you could risk heartache or huge vet's bills if you don't do your homework," a statement reads.
"By adopting and not shopping you'll also feel good for doing good - by giving an animal a second chance at life in a loving home!
"Plus, adopting from us means that you can relax knowing that all our animals are healthy, neutered, vaccinated and microchipped.
"As with all the animals we rehome, we'll pass on the details of their behaviour and veterinary treatment. You'll likely know more about your rescue animal's history than if you were to buy an animal online!
"We've taken the time to get to know each animal as an individual, to understand their likes and dislikes and to prepare them for life in a loving family, which means there are less likely to be nasty surprises when you get home!
"When you adopt a cat or a dog from one of our centres, you'll also get four weeks free pet insurance, which is vital to protect your pet's future as well as your bank balance! There's so much to gain from rescuing an animal in need."
If you're interested in rehoming one of the RSPCA's Laybourne Animal Centre's Cane Corso puppies, complete an online application form. The animal centre is open from 11am to 4pm on Thursdays and Tuesdays, by appointment only.
Do you have a dog story to share? Email paige.freshwater@reachplc.com.
