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The two drivers on a long-haul bus were killed and 44 passengers injured when it hit a steel support for a road sign in Nakhon Ratchasima early Tuesday morning.
The double-decker, operated by Lotusphibul Tours, was on the way from Bung Kan to Bangkok.
A rescue foundation said the accident happened at about 2am. The bus slammed into a steel post supporting a road sign.
Both the driver and relief driver were killed and 44 passengers were injured. Twelve of them were from Laos.
Police said four injured passengers were in serious condition and were admitted to a local hospital.