Cameron Winnett will make only his third start for Cardiff as Dai Young was forced into a back-three shuffle to face Bulls on Saturday.
The 19-year-old starts at full-back, with Ben Thomas switching to centre in place of Max Llewellyn, who damaged an ankle in Cardiff's 35-0 win against Sharks. Aled Summerhill replaces injured wing Theo Cabango, while Mason Grady, Kristian Dacey and Seb Davies also return to the starting XV.
Shane Lewis-Hughes is brought onto the bench after linking up with the squad, while Kirby Myhill and Harri Millard have also been named as replacements. The latter is line for his first competitive start of the season.
Cardiff director of rugby Young said: "We were really pleased with our performance and result last week against the Sharks, but this week presents an even greater challenge.
"The Bulls are a formidable side, arguably the most physical of the South African outfits, they had a good win against the Ospreys.
"We can take some confidence and momentum into the game but we are under no illusions of how big a challenge we face and we have to bring that same level of performance and intensity we saw last week."
Bulls: Kurt-Lee Arendse; David Kriel, Cornal Hendricks, Harold Vorster, Canan Moodie; Johan Goosen, Zak Burger; Gerhard Steenekamp, Johan Grobbelaar, Mornay Smith, Ruan Vermaak, Ruan Nortje (capt), Marco van Staden, Cyle Brink, Elrigh Louw.
Replacements : Jan-Hendrik Wessels, Simphiwe Matanzima, Francois Klopper, Janko Swanepoel, Nizaam Carr, Embrose Papier, Chris Smith, Lionel Mapoe.
Cardiff: Cameron Winnett; Jason Harries, Mason Grady, Ben Thomas, Aled Summerhill; Jarrod Evans, Lloyd Williams; Rhys Carré, Kristian Dacey, Dmitri Arhip, Lopeti Timani, Seb Davies, Josh Turnbull (capt.), Thomas Young, James Botham
Replacements: Kirby Myhill, Corey Domachowski, Will Davies-King, Teddy Williams, Shane Lewis-Hughes, James Ratti, Ellis Bevan, Harri Millard
Referee: Sam Grove-White (SRU)
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