Cameron Winnett will make only his third start for Cardiff as Dai Young was forced into a back-three shuffle to face Bulls on Saturday.
The 19-year-old starts at full-back, with Ben Thomas switching to centre in place of Max Llewellyn, who damaged an ankle in Cardiff's 35-0 win against Sharks. Aled Summerhill replaces injured wing Theo Cabango, while Mason Grady, Kristian Dacey and Seb Davies also return to the starting XV.
Shane Lewis-Hughes is brought onto the bench after linking up with the squad, while Kirby Myhill and Harri Millard have also been named as replacements. The latter is line for his first competitive start of the season.
