
The number of people with depression has reached new highs—and so has antidepressant use. As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight U.S. adults takes antidepressants—scientists have been innovating novel treatments for it.
There are dozens of antidepressants on the market, and they work extremely well for a lot of people. But they have little or no effect for as many as half those who try them. Until recently, all doctors could do was keep throwing more drugs at what seemed to be a largely impenetrable target.